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KMID : 1134820220510090894
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Journal of the Korean Society of Food Science and Nutrition
2022 Volume.51 No. 9 p.894 ~ p.904
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Effect of Euonymus alatus Extracts on Diabetes Related Markers in Pancreatic β-Cells and C57BL/Ksj-db/db Mice
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Kim Ye-Rin
Kim Eun-Young
Lee Seong-Uk
Kim Yong-Wan
Kim Yoon-Hee
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Abstract
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Euonymus alatus (Thunb.) Sieb is known to have anti-cancer and anti-inflammatory effects. This study aimed to reveal the effect of the water extract and 70% ethanol (70% EtOH) extract of Euonymus alaltus in INS-1 cells (pancreatic beta cell line) and C57BL/Ksj-db/db mice (type 2 diabetes models). The water extract significantly increased the proliferation of INS-1 cells. However, the extracts of Euonymus alatus water and 70% EtOH had no effect on increasing the insulin secretion in INS-1 cells. In the animal model of type 2 diabetes, the extracts of Euonymus alatus water and 70% EtOH decreased the water intake and effectively increased the pancreatic insulin concentration. Furthermore, exposure to the 70% EtOH extract resulted in decreasing the plasma triglycerides. These data indicate that the extracts of Euonymus alatus water and 70% EtOH exert a partial anti-diabetic effect.
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KEYWORD
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Euonymus alatus (Thunb.) Sieb, type 2 diabetes, INS-1, C57BL/Ksj-db/db
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